Two Patented Pre-Clinical Platforms
The development focus of Iasis Molecular Sciences is concentrated within wound care as well as antimicrobial coatings. Our two antimicrobial platforms allow for a deep pipeline that includes dressings, topical ointments, gels, alginates and other related devices which include wound drains. Our Congressionally Directed Medical Research Program (CRMRP) funded catheter project is a surrogate for our planned development of a next generation wound drain to alleviate biofilm-mediated infections in mastectomies and abdominal surgeries.
Our discovery that ionomers such as polystyrene sulfonate are inhibitors of inflammatory cell proteases, including high isoelectric point proteases and metalloproteinases, known to populate inflamed and infected wounds, led to the genesis of the antimicrobial ionomer, silver polystyrene sulfonate and other cation-modified ionomers. These silver-based ionomers were later color stabilized using chemical associates with thiols including glutathione. Later, we discovered that this association with a thiol greatly reduced the tissue-related toxicity of ionic silver and allowed for the synthesis and isolation of numerous new silver thiolates. This discovery led to our Platform No. 1 family of antiseptics.
The same chemical concepts were later applied to strong and weak ion exchange resins and with refined particle size reduction and incorporation into a variety of polymer matrices. The concept of self-disinfecting surfaces protected by our Platform No. 2 antimicrobials had arrived. The picture off to the right contains four individual members of our Platform No. 2 resins, each with its own unique set of properties.
The Iasis Molecular Sciences pipeline includes the following products from our two platforms: