Broad Spectrum Antiseptics for Wound Healing and Medical Device Coatings
Iasis Molecular Science’s (IMS) platform antiseptics are a family of novel silver-based complexes for the treatment of wound infections and for use as the active component of antimicrobial medical device coatings. These antiseptics offer excellent potency against drug-resistant pathogens, little concern of selection for resistance, lower cellular toxicity, and process benefits not found with commercial antiseptics. Currently marketed antiseptic solutions are toxic to human tissue, are not selective for microorganisms, and often interrupt healing processes where applied.
The mating of ionic silver with an antioxidant thiol compound ameliorates the inherent silver toxicity without degrading efficacy. Our platform antiseptics are color stable, readily tailorable across a range of potencies, and they are water and buffer soluble.
In-vivo pre-clinical evaluations have revealed that our Platform No. 1-treated infected wounds healed at a faster rate as compared to infected wounds treated with industry standard silver control dressings.
IMS antiseptics possess dramatically increased therapeutic indexes (TIs) as compared to currently accepted antiseptic agents.
Our Platform No. 1 family of antiseptics play a crucial role across the Iasis Molecular Sciences wound care and coating business. These antiseptics can be applied across several advanced dressings types, including foams, hydrocolloids, amorphous hydrogels, hydrogels, and alginates. Our antiseptics are readily formulated into multi-component polyurethane foams, polyvinylpyrrolidone (PVP), hydrophilic polyurethane coatings, and other water and organic-solvent-based coatings.
Platform No. 1 Antiseptics
Highly effective against a range of drug-resistant gram-positive and gram-negative bacteria and fungi.
Our polyurethane foams with silver-thiolates prevent the growth of drug-resistant gram-positive and gram-negative pathogens. Below is an example of the zones of inhibition seen in the Kirby Bauer assay.
Kirby Bauer Assay Showing the Zones of Inhibition from Platform No. 1
Applications for Platform No. 1 Antiseptics
Our antiseptics are broadly applicable to advanced wound dressings, topical wound therapies, alginates and medical device coatings.
Why Choose Our Antiseptics?